Polymorphism: rs11188059
rs11188059
(
SNPedia |
23andMe
)
Location: 10q24
Factor:
- Symbol: CYP2C
- Name: cytochrome P450, family 2, subfamily C, polypeptide 9
- Entrez ID: 1559
- Ensembl ID: ENSG00000138109
Factors:
CYP2C
cytochrome P450, family 2, subfamily C, polypeptide 9
(
1559
/
ENSG00000138109
)
Description:
Only one nominally significant association signal (rs11188059; pCCA = .04) was observed in the analysis of the centenarian sample (Table 1) that did not pass correction for multiple testing (Bonferroni-adjusted pCCA = 1, as-suming 56 tests; see “Participants and Methods” and “Statistical Analysis”).Overall, our results suggest that there is no noteworthy influence of sequence variation in the CYP2C genes on human longevity in Germans.
Ethnicity:
German
Statistics
- Number of cases/controls: 616 centenarians versus control group of 945 younger individuals (initial)
- p-value:
0.04
[0.04]
- Significant: yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology:
Reference:
21798861: Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.
Choice: Curate
Created: July 2, 2013, 2:33 a.m.
Updated: Aug. 26, 2013, 1:41 p.m.
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