Polymorphism: --1082G-->A


Location: 1q31-q32

Factor:
- Symbol: IL10
- Name: interleukin 10
- Entrez ID: 3586
- Ensembl ID: ENSG00000136634

Factors:
  • IL10 interleukin 10 ( 3586 / ENSG00000136634 )


  • Description:

    Applies to males only.

    Ethnicity: Italian
    Age of cases: >95
    Shorter lived allele: A
    Finding: Positive

    Statistics
    - Number of cases/controls: 109 (oldest old men) vs 263 (healthy controls) (initial)
    - p-value: 0.0001 [0.0001]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Taq-polymerase

    Reference:
    15466015: Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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