Denigma Buck Institute Health Extension
Polymorphism: rs1346044
rs1346044 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 8p12

Factor:
- Symbol: WRN
- Name: Werner syndrome, RecQ helicase-like
- Entrez ID: 7486
- Ensembl ID: ENSG00000165392

Factors:
  • WRN Werner syndrome, RecQ helicase-like ( 7486 / ENSG00000165392 )


    • Description:

    Leiden 85-plus Study. "In conclusion, the present study shows that the i1-C/T, L1074F [rs2725362] and C1367R variations in the WRN gene do not influence the sensitivity or resistance to... the course of aging."

    Trivial name is C1367R

    Ethnicity: Dutch
    Age of cases: >/= 85
    Finding: Negative

    Statistics
    - Number of cases/controls: cases: 1245 (Cohort '87: 682; Cohort '97: 563); vs controls: 247 (initial)
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: Assay-by-Design, qPCR core kit, Sequenom MassARRAYtm

    Reference:
    16405962: Impact of genetic variations in the WRN gene on age related pathologies and mortality.

    Choice: Clean
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 9, 2014, 11:32 p.m.

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