Polymorphism: rs3215173
rs3215173 ( SNPedia | 23andMe )

Location: 1q21

Factor:
- Symbol: SHC1
- Name: SHC (Src homology 2 domain containing) transforming protein 1
- Entrez ID: 6464
- Ensembl ID: ENSG00000160691

Factors:
  • SHC1 SHC (Src homology 2 domain containing) transforming protein 1 ( 6464 / ENSG00000160691 )


  • Description:

    Although not statistically significant, we found some notable differences in SHC1 between centenarians and younger controls... homozygotes for the minor allele of SNP2, SNP3, and SNP4 were found only among the younger controls.

    Ethnicity: Japanese
    Age of cases: Mean age 100.8 +/- 1.5
    Shorter lived allele: G/-

    Statistics
    - Number of cases/controls: 230 vs 180 (initial)
    - Odds ratio: 1.6
    - p-value: 0.15 [0.15]
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: BigDye Terminator cycle sequencing kit, ABI Prism 3700 DNA analyzer, Sequencher, PSQ 96, SNP reagent kit, SNPAlyze

    Reference:
    14530863: Association analysis of the SHC1 gene locus with longevity in the Japanese population.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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