Polymorphism: rs8191979
rs8191979 ( SNPedia | 23andMe )

Location: 1q21

Factor:
- Symbol: SHC1
- Name: SHC (Src homology 2 domain containing) transforming protein 1
- Entrez ID: 6464
- Ensembl ID: ENSG00000160691

Factors:
  • SHC1 SHC (Src homology 2 domain containing) transforming protein 1 ( 6464 / ENSG00000160691 )


  • Description:

    Although the frequencies were very low, SNP8 (1/460) was observed only in centenarians.

    Ethnicity: Japanese
    Age of cases: Mean age 100.8 +/- 1.5

    Statistics
    - Number of cases/controls: 230 vs 180 (initial)
    - p-value: 0.38 [0.38]
    - Significant: no

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: BigDye Terminator cycle sequencing kit, ABI Prism 3700 DNA analyzer, Sequencher, PSQ 96, SNP reagent kit, SNPAlyze

    Reference:
    14530863: Association analysis of the SHC1 gene locus with longevity in the Japanese population.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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