Polymorphism: APOE haplotype - rs1346044



rs1346044 ( SNPedia | 23andMe )

Variant Type: Haplotype
Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


  • Description:

    There was no significant association between rs1346044 and longevity, but it was between APOE haplotype and longevity.

    Ethnicity: Finn
    Age of cases: 100.8
    Shorter lived allele: e4
    Longer lived allele: e2
    Finding: Positive

    Statistics
    - Number of cases/controls: 175 vs 178 (initial)
    - p-value: 0.0001 [<0.0001]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    10069711: Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.

    Choice: Clean
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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