Polymorphism: rs2060793
rs2060793 ( SNPedia | 23andMe )

Location: 11p15.2

Factor:
- Symbol: CYP2R1
- Name: cytochrome P450, family 2, subfamily R, polypeptide 1
- Entrez ID: 120227
- Ensembl ID: ENSG00000186104

Factors:
  • CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 ( 120227 / ENSG00000186104 )


  • Description:

    "We found that familial longevity was associated with... a lower frequency of allelic variation in the CYP2R1 gene [rs2060793]." Also, may include not healthy individuals ("There was no selection based on health conditions or demographic characteristics.")

    Ethnicity: Dutch
    Age of cases: Males: >/= 89; Females: >/= 91

    Statistics
    - Number of cases/controls: 1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners) (initial)
    - p-value: 0.04 [0.04]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Illumina Infinium HD Human660W-Quad BeadChips, Illumina OmniExpress BeadChips

    Reference:
    23128285: Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 9, 2014, 11:31 p.m.

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