Polymorphism: rs2060793
rs2060793
(
SNPedia |
23andMe
)
Location: 11p15.2
Factor:
- Symbol: CYP2R1
- Name: cytochrome P450, family 2, subfamily R, polypeptide 1
- Entrez ID: 120227
- Ensembl ID: ENSG00000186104
Factors:
CYP2R1
cytochrome P450, family 2, subfamily R, polypeptide 1
(
120227
/
ENSG00000186104
)
Description:
"We found that familial longevity was associated with... a lower frequency of allelic variation in the CYP2R1 gene [rs2060793]." Also, may include not healthy individuals ("There was no selection based on health conditions or demographic characteristics.")
Ethnicity:
Dutch
Age of cases: Males: >/= 89; Females: >/= 91
Statistics
- Number of cases/controls: 1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners) (initial)
- p-value:
0.04
[0.04]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Illumina Infinium HD Human660W-Quad BeadChips, Illumina OmniExpress BeadChips
Reference:
23128285: Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 9, 2014, 11:31 p.m.
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