Polymorphism: 192
Location: 7q21.3
Factor:
- Symbol: PON1
- Name: paraoxonase 1
- Entrez ID: 5444
- Ensembl ID: ENSG00000005421
Factors:
PON1
paraoxonase 1
(
5444
/
ENSG00000005421
)
Description:
"For Italians, there was an increased frequency of QR heterozygotes and R allele in cases. For the Northern Irish, there was an increased frequency of RR homozygotes. ""...there was a small survival advantage for centenarian and
Ethnicity:
Irish
Age of cases: Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7
Shorter lived allele: Q
Statistics
- Number of cases/controls: Italian: 308 vs 579; Northern Irish: 296 vs 296 (initial)
- Odds ratio: 1.26
- p-value:
0.007
[0.007]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Sequencing
Reference:
15050299: Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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