Polymorphism: HP*1 F/S
Variant Type: Haplotype
Location: 16q22.2
Factor:
- Symbol: HP
- Name: haptoglobin
- Entrez ID: 3240
- Ensembl ID: ENSG00000257017
Factors:
HP
haptoglobin
(
3240
/
ENSG00000257017
)
Description:
"Given the significant association of HP1/1 genotype and HP1 allele with increased life-expectancy, we also performed HP1F/S subtyping to check the possible existence for a preferential advantage of HP1F or HP1S allele... No significant differences were noticed between age groups studied either considering total HP1F and HP1S allele frequencies... or according to HP 1/2 genotypes...". The population was divided into 3 sex-specific age classes: for men [women], Age Class 1: <66 years old [<73], Age Class 2: 66–88 [73–91], Age Class 3: >88 [>91]
Ethnicity:
Italian
Age of cases: >88
Finding: Negative
Statistics
- Number of cases/controls: 1072 total (initial)
- Odds ratio: 0.818
- p-value:
0.33
[0.33]
- Significant: No
Study Design
- Classifications:
No Age Effect
- Study type: Candidate Region/Gene
- Technology: Biometra T-gradient thermal-cycler
Reference:
21147083: Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.
Edit
(
Admin) |
Delete