Denigma Buck Institute Health Extension
Polymorphism: rs1800591
rs1800591 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 4q24

Factor:
- Symbol: MTTP
- Name: microsomal triglyceride transfer protein
- Entrez ID: 4547
- Ensembl ID: ENSG00000138823

Factors:
  • MTTP microsomal triglyceride transfer protein ( 4547 / ENSG00000138823 )


    • Description:

    Based on Leiden 85-Plus Study. Cross-sectional association analysis used to test for association of the MTP gene with longevity. "The allele frequencies did not differ between the case and control groups…" Prospective association analyses led to same conclusion.

    Initial number refers to octogenarians vs controls

    Ethnicity: Dutch
    Age of cases: Mean age 87.5±3.1
    Finding: Negative

    Statistics
    - Number of cases/controls: 655 vs 244 (initial)
    - p-value: 0.64 [0.64]
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Meta-Analysis
    - Technology: PCR based probes

    Reference:
    16611701: Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 9, 2014, 11:30 p.m.

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