Polymorphism: Lys751Gln
Location: 19q13.3
Factor:
- Symbol: ERCC2
- Name: excision repair cross-complementing rodent repair deficiency, complementation group 2
- Entrez ID: 2068
- Ensembl ID: ENSG00000104884
Factors:
ERCC2
excision repair cross-complementing rodent repair deficiency, complementation group 2
(
2068
/
ENSG00000104884
)
Ethnicity:
Polish
Age of cases: Mean age 101.1
Shorter lived allele: homozygous (Lys/Lys, Gln/Gln)
Longer lived allele: heterozygous (Lys/Gln)
Statistics
- Number of cases/controls: 149 vs 413 (initial)
- p-value:
0.017
[0.017]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: sequence specific probes
Reference:
19707883: Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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