Polymorphism: IL12B haplotypes
Location: 5q31.1-q33.1
Factor:
- Symbol: IL12B
- Name: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- Entrez ID: 3593
- Ensembl ID: ENSG00000113302
Factors:
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
(
3593
/
ENSG00000113302
)
Description:
"Analysis of IL-12B extended genotypes did not show any statistically significant associations despite of the slightly increased frequencies of (1188) C/C; (2124) A/A genotype in elderly... The functional relevance of the different distribution of this genotype remains to be clarified."
Ethnicity:
Italian,
Bulgarian
Age of cases: Age range: 65-99
Longer lived allele: 1188 C/C, 2124 A/A
Statistics
- Number of cases/controls: 470 vs 120 (initial)
- Significant: No
Study Design
- Classifications:
No Age Effect
- Study type: Candidate Region/Gene
- Technology: PCR-based sequencing
Reference:
21299522: 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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