Denigma Buck Institute Health Extension
Polymorphism: VNTR in intron 5 (DeltaEF1 site)







Location: 11p15.5

Factor:
- Symbol: SIRT3
- Name: sirtuin 3
- Entrez ID: 23410
- Ensembl ID: ENSG00000142082

Factors:
  • SIRT3 sirtuin 3 ( 23410 / ENSG00000142082 )


    • Description:

    Results only applies to males. LD between the silent marker G47TT (identified in exon 3 of SIRT3) and VNTR

    Ethnicity: Italian
    Age of cases: Median age 102
    Shorter lived allele: 2b

    Statistics
    - Number of cases/controls: 242 vs 703 (initial)
    - p-value: 8e-05 [8e-05]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: BigDye Terminator Cycle Sequencing Ready Reaction Kit (PE Applied Biosystems)

    Reference:
    15676284: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

    Choice: Curate
    Created: July 1, 2013, 1:03 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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