Polymorphism: rs1800896 - rs1800629
rs1800896 ( SNPedia | 23andMe )

rs1800629 ( SNPedia | 23andMe )

Variant Type: Haplotype
Location: 1q31-q32; 6p21.3

Factor:
- Symbol: IL10
- Name: interleukin 10
- Entrez ID: 3586
- Ensembl ID: ENSG00000136634

Factors:
  • IL10 interleukin 10 ( 3586 / ENSG00000136634 )
  • TNFa tumor necrosis factor ( 7124 / ENSG00000232810 )

  • Ethnicity: Italian
    Age of cases: >100
    Longer lived allele: GG-GG (only in men)
    Finding: Positive

    Statistics
    - Number of cases/controls: 174 vs 224 (initial)
    - p-value: 0.038 [0.038 (only in men)]
    - Significant: yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    12676903: Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP.

    Choice: Clean
    Created: July 1, 2013, 12:55 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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