Denigma Buck Institute Health Extension
Polymorphism: rs2075650
rs2075650 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


    • Description:

    The major locus determining familial longevity up to high age as detected by GWAS is marked by rs2075650, which tags the deleterious effects of the ApoE epsilon4 allele [21418511].

    Ethnicity: Dutch
    Age of cases: mean 94
    Shorter lived allele: e4
    Finding: Positive

    Statistics
    - Number of cases/controls: 403 vs 1670 (initial) | 4149 vs 7582 (replication)
    - Odds ratio: 0.71
    - p-value: 3.39e-17 [3.39e-17]
    - Significant: yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Genome-Wide Association Study
    - Technology: Not reported

    Reference:
    21418511: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

    Choice: Curate_Jimi
    Created: July 1, 2013, 12:39 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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