Denigma Buck Institute Health Extension
Polymorphism: rs3211994
rs3211994 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1q22

Factor:
- Symbol: NTLH1
- Name: nescient helix loop helix 1
- Entrez ID: 4807
- Ensembl ID: ENSG00000171786

Factors:
  • NTLH1 nescient helix loop helix 1 ( 4807 / ENSG00000171786 )


    • Description:

    Only significant in males.

    Ethnicity: Danish
    Age of cases: 92-93 years old
    Shorter lived allele: G
    Longer lived allele: A
    Finding: Positive

    Statistics
    - Number of cases/controls: 1089 vs 736 (initial) | 1613 vs 1104 (replication)
    - Odds ratio: 1.994
    - p-value: 0.0056 [0.0056]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Illumina GoldenGate platform

    Reference:
    22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

    Choice: Curate_Emily
    Created: July 1, 2013, 10:47 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

    Edit (Admin) | Delete