Polymorphism: rs2866164
rs2866164
(
SNPedia |
23andMe
)
Location: 4q24
Factor:
- Symbol: MTP
- Name: microsomal triglyceride transfer protein
- Entrez ID: 4547
- Ensembl ID: ENSG00000138823
Factors:
MTP
microsomal triglyceride transfer protein
(
4547
/
ENSG00000138823
)
Description:
"MTP CC genotype is significantly overrepresented in centenarians .. However, ... we observed a monotonic decline between ages 55–85 years followed by a dramatic enrichment after age 90 years, forming a U-shape pattern (p < .05). "
Ethnicity:
Ashkenazi Jewish
Age of cases: Mean age 97
Shorter lived allele: non-CC
Longer lived allele: CC
Statistics
- Number of cases/controls: 205 vs 288 (initial)
- p-value:
0.05
[0.05]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
22496539: Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.
Choice: Curate_Emily
Created: July 1, 2013, 10:42 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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