Denigma Buck Institute Health Extension
Polymorphism: rs507879
rs507879 ( SNPedia | 23andMe )

Location: 11q22.2-q22.3

Factor:
- Symbol: CASP5
- Name: caspase 5, apoptosis-related cysteine peptidase
- Entrez ID: 838
- Ensembl ID: ENSG00000137757

Factors:
  • CASP5 caspase 5, apoptosis-related cysteine peptidase ( 838 / ENSG00000137757 )


    • Description:

    Depletion of CASP5 Ala90Thr heterozygous genotype in the elderly.

    Ethnicity: Russian
    Age of cases: 75–103
    Shorter lived allele: AG
    Longer lived allele: AA, GG

    Statistics
    - Number of cases/controls: 510 vs 549 (initial)
    - p-value: 1.4e-05 [1.4e-05]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Allele-specific PCR

    Reference:
    20434535: Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.

    Choice: Curate_Johnny
    Created: July 1, 2013, 10:06 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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