Polymorphism: HLA-DRB1 13 generic DRB1 alleles






Location: 6p21.3

Factor:
- Symbol: HLA-DRB1
- Name: major histocompatibility complex, class II, DR beta 1
- Entrez ID: 3123
- Ensembl ID: ENSG00000196126

Factors:
  • HLA-DRB1 major histocompatibility complex, class II, DR beta 1 ( 3123 / ENSG00000196126 )


  • Description:

    Candidate gene

    Ethnicity: French
    Age of cases: 100+ and 90+ siblings
    Shorter lived allele: non-DR7 alleles
    Longer lived allele: DR7

    Statistics
    - Number of cases/controls: 152 vs 2950 (initial) | 208 vs original 2950 (replication)
    - Odds ratio: 1.72
    - p-value: 0.01
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Reverse dot-blot (Murex Diagnostics Inno-Lipa DRB1)

    Reference:
    9425225: HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity.

    Choice: Curate_Johnny
    Created: June 30, 2013, 11:53 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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