Polymorphism: rs12050077
rs12050077 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1p13

Factor:
- Symbol: TSHR
- Name: thyroid stimulating hormone receptor
- Entrez ID: 7253
- Ensembl ID: ENSG00000165409

Factors:
  • TSH-B thyroid stimulating hormone, beta ( 7252 / ENSG00000134200 )


  • Description: Ethnicity: Ashkenazi Jewish
    Age of cases: Median age 97
    Shorter lived allele: G
    Longer lived allele: A
    Finding: Positive

    Statistics
    - Number of cases/controls: 232 vs 163 (initial)
    - Odds ratio: 1.68
    - p-value: 0.0001 [0.0001]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR & sequencing

    Reference:
    19837933: Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.

    Choice: Curate_Johnny
    Created: June 30, 2013, 11:53 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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