Polymorphism: rs708272
rs708272
(
SNPedia |
23andMe
)
Variant Type: SNP
Location: 16q21
Factor:
- Symbol: CETP
- Name: cholesteryl ester transfer protein, plasma
- Entrez ID: 1071
- Ensembl ID: ENSG00000087237
Factors:
CETP
cholesteryl ester transfer protein, plasma
(
1071
/
ENSG00000087237
)
Description:
The heterozygous (GA) and homozygous (AA) genotypes for Taq1B were associated with similar reductions in overall mortality of 3% (HR: 0.97, 95% CI: 0.90 to 1.04) and 11% (HR: 0.89, 95% CI: 0.82 to 0.98), respectively, compared with wild type (GG).
Ethnicity:
Danish
Age of cases: 20-93, followed for up to 34 years
Shorter lived allele: GG
Longer lived allele: non-GG
Finding: Positive
Statistics
- Number of cases/controls: 10261 (initial)
- p-value:
0.02
[0.02]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Not described
Reference:
23083790: Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects.
Choice: Clean
Created: Aug. 25, 2013, 7:59 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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