Denigma Buck Institute Health Extension
Polymorphism: rs1061581-rs1043618-rs2227956
rs1061581-rs1043618-rs2227956 ( SNPedia | 23andMe )

Variant Type: Haplotype
Location: 6p21.3


Factors:
  • HSPA1A heat shock 70kDa protein 1A ( 3303 / ENSG00000204389 )
  • HSPA1B heat shock 70kDa protein 1A ( 3303 / ENSG00000204389 )
  • HSPA1L heat shock 70kDa protein 1-like ( 3305 / ENSG00000204390 )


    • Description:

    Haplotype factors are in the following order: HSPA1B-HSPA1A-HSPA1L

    Ethnicity: Chinese
    Age of cases: >90
    Shorter lived allele: non A-G-C or non A-C-T haplotypes
    Longer lived allele: A-G-C
    Finding: Positive

    Statistics
    - Number of cases/controls: 191 vs 53 (initial)
    - Odds ratio: 3.46
    - p-value: 0.025 [0.025]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR based probes

    Reference:
    19840767: Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity.

    Choice: Curate
    Created: Aug. 11, 2013, 8:23 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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