Polymorphism: −438 G/A
Location: 13q14.11
Factor:
- Symbol: TAFI
- Name: carboxypeptidase B2 (plasma)
- Entrez ID: 1361
- Ensembl ID: ENSG00000080618
Factors:
TAFI
carboxypeptidase B2 (plasma)
(
1361
/
ENSG00000080618
)
Description:
Men with the TAFI −438 A/A genotype had decreased mortality due to all causes, and lived, on average, 0.9 more years of life, or 1.1 more years of healthy life, than men with the −438 G allele. The effects of TAFI −438 G/A in women were smaller and not statistically significant. Detailed OR information is as follows: 0.53 (0.32–0.87).
Ethnicity:
American,
Caucasian
Age of cases: 65+
Shorter lived allele: G (men)
Finding: Positive
Statistics
- Number of cases/controls: 2224 (initial)
- Odds ratio: 0.53
- p-value:
0.003
[0.003]
- Significant: Yes
Study Design
- Classifications:
No Age Effect
- Study type: Candidate Region/Gene
- Technology: N/A
Reference:
15939070: Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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