Polymorphism: rs915179-rs2485662-rs4641-rs1468772
rs915179-rs2485662-rs4641-rs1468772
(
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23andMe
)
Variant Type: Haplotype
Location: 1q22
Factor:
- Symbol: LMNA
- Name: lamin A/C
- Entrez ID: 4000
- Ensembl ID: ENSG00000160789
Factors:
LMNA
lamin A/C
(
4000
/
ENSG00000160789
)
Description:
There were no significant single-SNP associations with longevity after correction for multiple testing via permutation tests. However, there was an observed association with longevity involving the GTCT haplotype of SNPs rs915179, rs2485662, rs4641, and rs1468772
Ethnicity:
American,
Caucasian
Age of cases: Mean age 101.5
Longer lived allele: GTCT
Finding: Positive
Statistics
- Number of cases/controls: 873 vs 443 (initial)
| New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) (replication)
- Odds ratio: 1.56
- Odds ratio type: Longer
- p-value:
2.5e-05
[0.000025]
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: Meta-analysis
Reference:
22340368: Human longevity and common variations in the LMNA gene: a meta-analysis.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 9, 2014, 11:43 p.m.
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