Polymorphism: rs429358, rs7412
rs429358,
(
SNPedia |
23andMe
)
rs7412
(
SNPedia |
23andMe
)
Location: 19q13.2
Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203
Factors:
APOE
apolipoprotein E
(
348
/
ENSG00000130203
)
Description:
Consistent with the increase in haplotype frequencies with age, the APOE haplotype is associated with exceptional survival in the European-origin subpopulations from both Georgia and Louisiana, with OR of 1.53 (CI = 1.08–2.17; Exact P = 2.12 · 10)2; adjusted P = 2.12 · 10)2) and 1.37 (CI = 1.02–1.83; Exact P = 4.37 · 10)2; adjusted P = 4.37 · 10)2) respectively [20569235].
Ethnicity:
African European
Age of cases: Range: 20-59
Statistics
- Number of cases/controls: 60 vs 89 (initial)
- p-value:
0.0212
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
Reference:
20569235: HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.
Choice: Curate
Created: July 2, 2013, 6:26 p.m.
Updated: Aug. 26, 2013, 3:32 p.m.
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