Polymorphism: rs132793
rs132793 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 22q13.2

Factor:
- Symbol: XRCC6
- Name: X-ray repair complementing defective repair in Chinese hamster cells 6
- Entrez ID: 2547
- Ensembl ID: ENSG00000196419

Factors:
  • XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 ( 2547 / ENSG00000196419 )


  • Description:

    XRCC6 variant was not associated with longevity, though it had a significant effect on telomere length.

    Ethnicity: Caucasian, European
    Age of cases: 90-103, 98+ (replication)
    Finding: Negative

    Statistics
    - Number of cases/controls: 224 vs 293 (initial) | 170 vs 220 (replication)
    - p-value: 0.74 [ N/A]
    - Significant: No

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: Illumina GoldenGate

    Reference:
    21972126: Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:17 p.m.

    Edit (Admin) | Delete