Polymorphism: rs7896005
rs7896005
(
SNPedia |
23andMe
)
Location: 10q21.3
Factor:
- Symbol: SIRT1
- Name: sirtuin 1
- Entrez ID: 23411
- Ensembl ID: ENSG00000096717
Factors:
SIRT1
sirtuin 1
(
23411
/
ENSG00000096717
)
Description:
The SIRT1 locus was significantly associated with longevity (P<0.003). The association of the same variant of SIRT1 with longevity was near significant (P<0.07) in a second population. Detailed OR information is as follows: 2.382 (1.355–4.282). 1.334 (0.978–1.824) for replication
Ethnicity:
Caucasian,
European
Age of cases: 90-103, 98+ (replication)
Shorter lived allele: G
Statistics
- Number of cases/controls: 224 vs 293 (initial)
| 170 vs 220 (replication)
- Odds ratio: 2.382
- p-value:
0.003
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: Illumina GoldenGate
Reference:
21972126: Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:18 p.m.
Edit
(
Admin) |
Delete