Denigma Buck Institute Health Extension
Polymorphism: REN polymorphism - mtDNA





Variant Type: Haplotype
Location: 1q32

Factor:
- Symbol: mtDNA
- Name: renin
- Entrez ID: 5972
- Ensembl ID: ENSG00000143839

Factors:
  • mtDNA renin ( 5972 / ENSG00000143839 )


    • Description:

    A significant interaction between REN gene allele 10 and the mitochondrial H haplotype, which may favour longevity, was found. Both genes had been reported to exhibit no effect on survival alone. However, carriers of the two genes have a significantly increased probability of achieving a long life. Detailed OR information is as follows: 3.274 (1.405 ± 7.630)

    Ethnicity: Italian
    Age of cases: 100+
    Longer lived allele: REN10 - mtDNA haplogroup H
    Finding: Positive

    Statistics
    - Number of cases/controls: 157 (initial)
    - Odds ratio: 3.274
    - Odds ratio type: Longer
    - p-value: 0.006
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: N/A

    Reference:
    11938442: A centenarian-only approach for assessing gene-gene interaction in human longevity.

    Choice: Clean
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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