Denigma Buck Institute Health Extension
Polymorphism: rs7788972
rs7788972 ( SNPedia | 23andMe )

Location: 7p21.1

Factor:
- Symbol: HDAC9
- Name: histone deacetylase 9
- Entrez ID: 9734
- Ensembl ID: ENSG00000048052

Factors:
  • HDAC9 histone deacetylase 9 ( 9734 / ENSG00000048052 )


    • Description:

    HERE IS USED NOT Odds RATIO TO BECOME CENTENARIAN BUT Hazard RATIO (to die younger or to have CVD or any other negative event during the study). Alleles are shown as authors mention them (in general dbSNPs and author`s designations are similar)

    Ethnicity: American
    Shorter lived allele: A

    Statistics
    - Number of cases/controls: 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) (initial) | Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project (replication)
    - Odds ratio: 1.0932
    - p-value: 3.73e-05 [0.0000373]
    - Significant: Nominally yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Genome-Wide Association Study
    - Technology: Version 3 Illumina Infinium II HumanHap550 SNP chip array, Illumina 370CNV, Affymetrix GeneChip SNP Array 6.0, Illumina 370CNV, Illumina 550K, Illumina 550K, Illumina Human1M-Duo, Affymetrix SNP Array 6.0, respectively.

    Reference:
    21782286: A genome-wide association study of aging.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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