Polymorphism: rs769449
rs769449 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )

  • Ethnicity: Danish, German
    Age of cases: 92-93 Danish, 95–110 German
    Shorter lived allele: G

    Statistics
    - Number of cases/controls: 1,089 vs 736 (initial) | 1,613 vs 1,104 (replication)
    - Odds ratio: 0.7
    - p-value: 0.018
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Technology: "Illumina GoldenGate, Sequenom MassARRAY

    Reference:
    22234866: Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 26, 2013, 12:28 p.m.

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