Polymorphism: 192 (Q/R)



Location: 7q21.3

Factor:
- Symbol: PON1
- Name: paraoxonase 1
- Entrez ID: 5444
- Ensembl ID: ENSG00000005421

Factors:
  • PON1 paraoxonase 1 ( 5444 / ENSG00000005421 )


  • Description:

    There was a small survival advantage for centenarian and octo/nonagenarian subjects who were heterozygous for PON1 192 R allele. Detailed OR information is as follows: 1.3 (1-1.5)

    Ethnicity: Irish, Italian
    Age of cases: Italian 100.8 years, Irish 89.8 years
    Shorter lived allele: Q

    Statistics
    - Number of cases/controls: 308 vs 579 Italian, 296 vs 296 Irish (initial)
    - Odds ratio: 1.3
    - p-value: 0.007
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: PCR-RFLP

    Reference:
    15050299: Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

    Edit (Admin) | Delete