Polymorphism: 192 (Q/R)
Location: 7q21.3
Factor:
- Symbol: PON1
- Name: paraoxonase 1
- Entrez ID: 5444
- Ensembl ID: ENSG00000005421
Factors:
PON1
paraoxonase 1
(
5444
/
ENSG00000005421
)
Description:
There was a small survival advantage for centenarian and octo/nonagenarian subjects who were heterozygous for PON1 192 R allele. Detailed OR information is as follows: 1.3 (1-1.5)
Ethnicity:
Irish,
Italian
Age of cases: Italian 100.8 years, Irish 89.8 years
Shorter lived allele: Q
Statistics
- Number of cases/controls: 308 vs 579 Italian, 296 vs 296 Irish (initial)
- Odds ratio: 1.3
- p-value:
0.007
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: PCR-RFLP
Reference:
15050299: Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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