Polymorphism: BRCA1 haplotypes



Variant Type: Haplotype
Location: 17q21

Factor:
- Symbol: BRCA1
- Name: breast cancer 1, early onset
- Entrez ID: 672
- Ensembl ID: ENSG00000012048

Factors:
  • BRCA1 breast cancer 1, early onset ( 672 / ENSG00000012048 )


  • Description:

    Initial results obtained with two-dimensional gene scanning (TDGS) suggest differences in BRCA1 genotype frequencies between the centenarian populations and controls.

    Ethnicity: New England American, Italian
    Age of cases: >100
    Shorter lived allele: b
    Finding: Negative

    Statistics
    - Number of cases/controls: 102 vs 97 (initial) | 82 vs 97 (replication)
    - Significant: No

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: Two-dimensional gene scanning (TDGS)

    Reference:
    11795532: BRCA1 gene sequence variation in centenarians.

    Choice: Clean
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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