Polymorphism: HUMTHO1 (STR), haplogroups




Location: 18p11.32

Factor:
- Symbol: THO, mtDNA
- Name: THO complex 1
- Entrez ID: 9984
- Ensembl ID: ENSG00000079134

Factors:
  • THO, mtDNA THO complex 1 ( 9984 / ENSG00000079134 )


  • Description:

    Personally me, I do not understand results of the study. Authors claim THOs VNTR long alleles as a risk factor (according to PMID:9887369) and in this study theyve observed association between THO long alleles frequency and U haplogroup of mtDNA in centenarians... And what?

    Ethnicity: Italian
    Age of cases: 100-105
    Shorter lived allele: Long alleles + U haplogroup
    Finding: Positive

    Statistics
    - Number of cases/controls: 202 (55m, 145 f) vs 82 (43 m, 39 f) (initial)
    - p-value: 0.045 [0.045]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    11053670: Does a retrograde response in human aging and longevity exist?

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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