Polymorphism: HUMTHO1 (STR), haplogroups
Location: 18p11.32
Factor:
- Symbol: THO, mtDNA
- Name: THO complex 1
- Entrez ID: 9984
- Ensembl ID: ENSG00000079134
Factors:
THO, mtDNA
THO complex 1
(
9984
/
ENSG00000079134
)
Description:
Personally me, I do not understand results of the study. Authors claim THOs VNTR long alleles as a risk factor (according to PMID:9887369) and in this study they
ve observed association between THO long alleles frequency and U haplogroup of mtDNA in centenarians... And what?
Ethnicity:
Italian
Age of cases: 100-105
Shorter lived allele: Long alleles + U haplogroup
Finding: Positive
Statistics
- Number of cases/controls: 202 (55m, 145 f) vs 82 (43 m, 39 f) (initial)
- p-value:
0.045
[0.045]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
11053670: Does a retrograde response in human aging and longevity exist?
Choice: Curate
Created: July 2, 2013, 2:54 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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