Polymorphism: K153R
Variant Type: SNP
Location: 2q32.2
Factor:
- Symbol: MSTN
- Name: myostatin
- Entrez ID: 2660
- Ensembl ID: ENSG00000138379
Factors:
MSTN
myostatin
(
2660
/
ENSG00000138379
)
Description:
The frequency of the variant R allele was significantly higher in centenarians (7.1 %) than in controls (2.7 %) (P=0.001). The odds ratio of being a centenarian if the subject had the R allele was 3.48. Detailed OR information is as follows: 3.48 (1.67–7.28)
Ethnicity:
Italian,
Spaniard
Age of cases: 100–111
Shorter lived allele: K
Statistics
- Number of cases/controls: 156 vs 384 (initial)
| 79 vs 316 (replication)
- Odds ratio: 3.48
- p-value:
0.001
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: PCR, single-base extension (SBE)
Reference:
23354683: Association of the K153R polymorphism in the myostatin gene and extreme longevity.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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