Denigma Buck Institute Health Extension
Polymorphism: rs429358, rs7412
rs429358, ( SNPedia | 23andMe )
rs7412 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


    • Description:

    This study utilizes meta-analysis of particular dataset with the use of novel statistical algorithm (genetic-demographic approach).

    Ethnicity: Italian
    Age of cases: 18-109
    Shorter lived allele: e4
    Longer lived allele: non-e4
    Finding: Positive

    Statistics
    - Number of cases/controls: 1477 total (initial)
    - p-value: 0.009 [<0.009 (females had even lower p-value)]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: -
    - Technology:

    Reference:
    16896546: Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci).

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 26, 2013, 3:26 p.m.

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