Polymorphism: Q/H 95



Location: 4q24

Factor:
- Symbol: MTP
- Name: microsomal triglyceride transfer protein
- Entrez ID: 4547
- Ensembl ID: ENSG00000138823

Factors:
  • MTP microsomal triglyceride transfer protein ( 4547 / ENSG00000138823 )


  • Description:

    There were several confirmatory studies, one in USA cohort, second - in French. I`ve mentioned French cohort as second study. Noteworthy to say, that highly appreciated (by autors) genotype combination rs2866164 / MTP Q/H95 has no statistically significant differencies in the replication study in French cohort.

    pvalue = 0.071 (0.55) (invalid literal for float(): 0.071(0.55))

    Ethnicity: American, Caucasian
    Age of cases: Mean 100,8
    Shorter lived allele: Q95
    Longer lived allele: H95

    Statistics
    - Number of cases/controls: 653 (197 m, 456 f) vs non-mentioned (initial) | 564 (92 m, 472 f) vs 564___(Franch Caucasians) (replication)
    - p-value: [0.071 (0.55)]
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Genome-Wide Association Study
    - Technology: Sequenom's chip-based matrix-assisted laser desorption/ionization time-of-flight MS and RT-PCR

    Reference:
    14615589: Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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