Polymorphism: HUMTHO1.STR
Variant Type: STR
Location: 11p15.5
Factor:
- Symbol: TH
- Name: tyrosine hydroxylase
- Entrez ID: 7054
- Ensembl ID: ENSG00000180176
Factors:
TH
tyrosine hydroxylase
(
7054
/
ENSG00000180176
)
Description:
Allele 10 (10 imperfect repeats) shows a remarkable dominant and beneficial effect that reduces the log hazard of death in an additive manner. Detailed OR data is as follows: Heterozygous 10: 0.92, and homozygous 10: 0.851. P-value data: Heterozygous 10: 0.013; homozygous 10*: 0.005.
Other alleles (6, 7, 8, 9, 10) seem to have no significant influence on longevity.
Ethnicity:
Italian
Age of cases: 100+
Longer lived allele: 10* (imperfect allele 10)
Finding: Positive
Statistics
- Number of cases/controls: 210 vs 755 (initial)
- Odds ratio: 0.851
- Odds ratio type: Shorter
- p-value:
0.005
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: PCR, ABIPRISM 310 Genetic Analyzer
Reference:
12297342: The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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