Polymorphism: rs4646994
rs4646994
(
SNPedia |
23andMe
)
Alias: rs4340; rs1799752; rs13447447
Variant Type: Deletion
Location: 17q23.3
Factor:
- Symbol: ACE
- Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Entrez ID: 1636
- Ensembl ID: ENSG00000159640
Factors:
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
(
1636
/
ENSG00000159640
)
Description:
This is an in/del polymorphism. The overall distributions of alleles in these three ethnic groups did not differ significantly. Within the Uighur group, frequency of the D allele was significantly higher in the very old group (0.448) than in the old group (.448),
odds_ratio = N/A
pvalue = .04
Ethnicity:
Chinese
Age of cases: Old: 59-70, Very old 90-113
Shorter lived allele: I (insertion)
Statistics
- Number of cases/controls: 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals (initial)
- p-value:
0.04
[0.04 ]
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: PCR, gel electrophoresis
Reference:
11773214: Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study.
Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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