Polymorphism: mt146 C>T



Variant Type: SNP



Description:

C allele at mt146 appeared to be significantly associated with longevity, while mt146T had opposing effect. mt5178 had no effect on longevity in Chinese Bama population.

Ethnicity: Chinese
Age of cases: 90-110
Shorter lived allele: mt146T
Longer lived allele: mt146C
Finding: Positive

Statistics
- Number of cases/controls: 113 (cases) vs 200 (initial)
- p-value: 0.005 [<0.0005 (mt146T), <0.005]
- Significant: Yes

Study Design
- Study type: Complete Mitochondrial Genome
- Technology: Applied Biosystems 3730 automated DNA sequencer

Reference:
22729909: Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China.

Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 26, 2013, 3:53 p.m.

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