Denigma Buck Institute Health Extension
Polymorphism: rs2075650
rs2075650 ( SNPedia | 23andMe )

Location: 19q13

Factor:
- Symbol: TOMM40
- Name: translocase of outer mitochondrial membrane 40 homolog (yeast)
- Entrez ID: 10452
- Ensembl ID: ENSG00000130204

Factors:
  • TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) ( 10452 / ENSG00000130204 )


    • Description:

    Significant after meta-analysis it is highly significant with OR 0,71 and p-value 3.39x10^-17.

    Ethnicity: Dutch
    Age of cases: Mean age 94
    Shorter lived allele: G

    Statistics
    - Number of cases/controls: 403 vs 1670 (initial) | 3746 vs 5912 (replication)
    - Odds ratio: 0.53
    - p-value: 2.65e-06 [2.65x10^-6]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Genome-Wide Association Study
    - Technology: Illumina Infinium HD Human660W-Quad BeadChips; Illumina Infinium II HumanHap550-Duo BeadChips

    Reference:
    21418511: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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