Polymorphism: rs10047589
rs10047589
(
SNPedia |
23andMe
)
Variant Type: SNP
Location: 12q23-q24.
Factor:
- Symbol: TXNRD1
- Name: thioredoxin reductase 1
- Entrez ID: 7296
- Ensembl ID: ENSG00000198431
Factors:
TXNRD1
thioredoxin reductase 1
(
7296
/
ENSG00000198431
)
Description:
In the following SNPs they did follow-up survival data for long lived individuals. When cases vs controls were Early/Late death. Replication cases age: 85 w/ 10.35 follow-up. Replication ethnicity: Dutch. Gene typo: written as TNXRD1, should be TXNR1.
Ethnicity:
Danish
Age of cases: 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up
Shorter lived allele: G
Finding: Positive
Statistics
- Number of cases/controls: 1089 (see notes - follow-up study) (initial)
| 563 (see notes - follow-up study) (replication)
- Odds ratio: 1.458
- p-value:
0.043
[0.043]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
Reference:
22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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