Denigma Buck Institute Health Extension
Polymorphism: rs3772190
rs3772190 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 5p15.33

Factor:
- Symbol: TERC
- Name: telomerase RNA component
- Entrez ID: 7012

Factors:
  • TERT telomerase reverse transcriptase ( 7015 / ENSG00000164362 )


    • Description:

    "... although the finding did not remain significant after Bonferroni step-down correction (P-corrected = 0.108 using a dominant model and P = 0.153 for comparison of GG vs. AG). If instead applying the less conservative Benjamini and Hochberg correction method, the P-values were 0.108 for the dominant model and 0.081 for GG vs. AG, respectively"

    Ethnicity: Danish
    Shorter lived allele: A
    Longer lived allele: G
    Finding: Positive

    Statistics
    - Number of cases/controls: 1013 total (initial)
    - p-value: 0.006 [0.006]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: TaqMan SNP genotyping assays

    Reference:
    22136229: Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

    Edit (Admin) | Delete