Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
mtDNA haplotype — — 0.0052 212 vs 275 — Italian 100+ non-J haplogroups — Mitochondrial Haplogroup 10463944
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years Q — Candidate Region/Gene 15050299
apoE haplotypes — — 0.02 80 vs 391 — Greek 80+ Apo e4 — Candidate Region/Gene 17234815
?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
apoE haplotypes — — 0.0042 3924 — American 5-70 Apo e4 — Candidate Region/Gene 21332925
rs11235972 UCP3 — 0.029 908 vs 708 — Danish 93 A — Candidate Region/Gene 22743239
rs1685354 UCP3 — 0.762 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
rs3781907 UCP3 — 0.05 908 vs 708 — Danish 93 G — Candidate Region/Gene 22743239
rs647126 UCP3 — 0.447 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
82133 G>A — — 0.0189 33 vs 39 — Japanese 90+ A — Candidate Region/Gene 15820493
APOE e2/e3/e4 APOE 4.40 0.02 179 — Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination — 3.19 0.0006 208 vs 514 — Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
rs2802288 FOXO3A 1.51 0.003 281 vs 195 — Italian 90–108 G A Candidate Region/Gene 19415983
rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
rs1800896 IL10 — 0.031 119 vs 118 — Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
rs1799752 ACE — 0.016 12 vs 190 vs 105 — Greek 99-111 D I Candidate Region/Gene 23389097
rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
- Insulin signaling pathway (IIS) — 0.01 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
- Telomere maintenance pathway (TM) — 0.02 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
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