Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    Mitochondrial haplogroups mtDNA 0.001 225 (cases) vs 400 middle aged vs 257 infants Finn 90-91 H U, J, K Mitochondrial Haplogroup 12483296
    HLA-A phenotype HLA-A 1.95 0.002 201 vs 211 Chinese 22 centenarians + 179 nonagenarians (mean age 93 ±1.04) A9 A30 Candidate Region/Gene 9147371
    HLA-C phenotype HLA-C 0.49 0.02 201 vs 211 Chinese >93 Cw3, Cw6. Cw7 Candidate Region/Gene 9147371
    5-HTTLPR SLC6A4 0.03 15 male, 53 female centenarians (cases) Australian, Caucasian 101.0 ± 0.2 L/L (only for males) Candidate Region/Gene 22985157
    Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 0.044 303 Human Minimum age 98 for one sibling (of sibship) Genome-Wide Association Study 11526246
    • 5 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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