Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


  • Variant type: + -

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
    SV-6 CLU 1.0 49 vs 27 vs 20 Greek, Italian 99–107 Candidate Region/Gene 16804001
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    rs1043618 HSP70-A1A 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
    rs6457452 HSP70-A1B 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
    rs28362491 NFkB 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs5882 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    H63D HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    S65C HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    56 SNPs - CYP2C gene family CYP2C gene family: CYP2C8, CYP2C9, CYP2C18, CYP2C19 1.0 1,384 vs 945 German Mean age 98.8 Candidate Region/Gene 21798861
    rs3758391 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs1885472 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs2273773 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs10997870 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs2234975 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs72533289 KIR2DS4 1.0 180 vs 180 Irish Mean age 89 Candidate Region/Gene 15130674
    rs1801274 FCGR2A 1.0 408 vs 446 vs 454 German Centenarians Candidate Region/Gene 16893392
    rs2866164 MTTP 1.0 1651 vs 575 Danish 92-93 Candidate Region/Gene 16015282
    CTSD CTSD 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    AGT AGT 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    TP53 TP53 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    DRD4 DRD4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    SLC6A4 SLC6A4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    rs662 PON1 1.0 579 vs 308 Italian Over 100 G A Candidate Region/Gene 12082503
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    • 25 of 784 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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