Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4537545 IL6R 3e-18 308 American, European, Ashkenazi Jewish 75.7 Candidate Region/Gene 19249341
    HRAS1 LASS1 (CGT) APOE 6.91e-07 204 vs 251 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 1e-06 79 vs 88 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 9e-06 19 vs 73 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 1e-05 128 vs 115 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 4.1e-05 147 vs 188 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 7.8e-05 147 vs 188 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 9.5e-05 204 vs 251 American Candidate Region/Gene 20569235
    XRCC3 intron 3 STR 0.0005 430 (case) vs 290 British Mean age 70 15 13 Candidate Region/Gene 16518718
    XRCC5 120 bp 5` (GAPyA)n STR 0.0005 430 (case) vs 290 British Mean 70 16+2 15 Candidate Region/Gene 16518718
    SI000565Q APOB 0.001 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 LL Candidate Region/Gene 17393087
    rs11279109 - APOB XbaI APOB 0.001 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ Candidate Region/Gene 17393087
    HRAS1 LASS1 (CCT) APOE 0.00197 125 vs 163 American Candidate Region/Gene 20569235
    −438 G/A TAFI 0.53 0.003 2224 American, Caucasian 65+ G (men) Candidate Region/Gene 15939070
    rs189037 ATM 0.004 875 vs 886 Chinese mean 94.6 CT Candidate Region/Gene 20816691
    APOB XbaI − SI000565Q APOB 0.006 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
    rs11066301 PTPN11 0.0111 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    APOE polymorphism - HP1/2 common polymorphism APOE 0.013 200 (cases) vs 539 (initial) Italian >88 e4-H2 (haplotype) Candidate Region/Gene 21703254
    rs939915 SIRT3 0.0145 2461 samples (cases and controls combined) Italian Candidate Region/Gene 19367319
    rs6589722 0.015 209 vs 402 Japanese 95+ Candidate Region/Gene 23770741
    rs1800591 MTTP 0.032 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    V465A GABRR3 0.04 390 vs 410 Ashkenazi Jewish Centenarians Candidate Region/Gene 23376243
    VNTR DC-SIGNR 0.041 361 vs 342 Chinese >90 non-6/7 genotype 6/7 genotype Candidate Region/Gene 20003397
    rs11279109 - APOB XbaI - SI000565Q APOB 0.044 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    I carriers of ACE 0.045 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
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    • 25 of 382 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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