Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    - Insulin signaling pathway (IIS) 0.01 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
    - Telomere maintenance pathway (TM) 0.02 403 vs 1670 European 90-103 Genome-Wide Association Study 22113349
    3p24-22 3p24-22 0.037 3953 American Minimum age 98 Genome-Wide Association Study 20824210
    marker D4S1564 0.044 308 European min. age 98 for one sibling. 91+ males, 95+ females Genome-Wide Association Study 11526246
    rs326146 ADCY2 1.46 0.024 137 vs 213 Korean Mean age 90 A Genome-Wide Association Study 19641380
    rs155979 PCSK1 0.61 0.012 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs3811952, rs155979, rs3762985 0.54 0.008 137 vs 213 Korean Mean age 90 CGA Genome-Wide Association Study 19641380
    rs4237973 PIK3C2G 1.51 0.022 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs1800802 MGP 0.77 0.132 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs1054016 TNFSF11 1.09 0.579 137 vs 213 Korean Mean age 90 T Genome-Wide Association Study 19641380
    rs327519 PAX4 (for males) 5.70 0.004 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs712700 1.87 0.01 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs327512 5.55 0.005 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs1980042 LYN (for males) 2.10 0.006 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs1979128 2.10 0.006 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs1450740, rs1450741, rs1562818, rs1980042, rs1027989, rs 1546518, rs3968371 3.72 0.002 137 vs 213 Korean Mean age 90 CTCCGCA Genome-Wide Association Study 19641380
    rs2274471 JAK2 (for males) 1.58 0.088 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs671 ALDH2 (for males) 2.11 0.009 137 vs 213 Korean Mean age 90 A Genome-Wide Association Study 19641380
    rs2030071 IL12RB2 (for females) 0.18 0.008 137 vs 213 Korean Mean age 90 T Genome-Wide Association Study 19641380
    rs2072454, rs2293347, rs3807362, rs884225 EGFR (for females) 4.11 0.003 137 vs 213 Korean Mean age 90 CGCA Genome-Wide Association Study 19641380
    rs3800358 BTBD9 0.00541 1173 vs 570 American 85-100 T Genome-Wide Association Study 22533364
    rs1974676 Intergenic 0.00496 1173 vs 570 American 85-100 G Genome-Wide Association Study 22533364
    rs1834497 CLSTN2 0.00979 1173 vs 570 American 85-100 A Genome-Wide Association Study 22533364
    rs2590504 KIAA0649 0.00854 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
    rs2024714 CDH4 7.43e-05 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
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    • 25 of 710 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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