Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
    rs5882 CETP 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
    rs769449 APOE 0.70 0.018 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German G 22234866
    rs1061170 CFH 1.78 0.005 491 vs 0 Finn His 19000922
    rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
    rs2149954 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
    rs429358, rs7412 APOE 0.009 1477 total Italian 18-109 e4 non-e4 - 16896546
    rs5882 CETP 3.56 0.001 213 vs 258 Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    rs1800896 IL10 3.10 0.0003 142 vs 153 Mean age 67 AA GG Candidate Region/Gene 15466015
    rs10149689 TSHR 1.56 0.001 232 vs 163 Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs5882 CETP 0.05 300 vs 320 vs 258 Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
    rs1800896 IL10 0.019 174 vs 227 Italian >100 GG Candidate Region/Gene 12676903
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs1207362 KL 0.63 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs2267723 GHRHR 0.70 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs3842755 INS 1.79 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old C A Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs11571461 RAD52 2.23 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs13251813 WRN 1.84 0.0002 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs1805329 RAD23B 0.72 0.0309 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs2953983 POLB 1.60 0.0225 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs1799945 HFE 0.008 57 vs 60 Italian 100-105 Candidate Region/Gene 12714263
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    • 25 of 243 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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