Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 Italian age 99–109,years, mean age 101 years; 26 men, 111 women Candidate Region/Gene 16799135
    APOE4 APOE 0.013 35 vs 125 Chinese 90 years or over High E4 frequency Candidate Region/Gene 11780357
    rs5882 CETP 3.56 0.001 213 vs 258 Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    APOE4 APOE 0.71 106 vs 349 American 70-79 (duration of study - 7 years) e4 Candidate Region/Gene 16799145
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young Italian 91+ (very old), 73-91 (old) G C Candidate Region/Gene 23125046
    rs1800896 IL10 3.10 0.0003 142 vs 153 Mean age 67 AA GG Candidate Region/Gene 15466015
    Apo C-I 1>2 Apo C-I 0.05 282 vs 200 British 84+ Apo C-I 2 Candidate Region/Gene 9105559
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish 100+ A Candidate Region/Gene 16602826
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    APOE e2/e3/e4 APOE 4.40 0.02 179 Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    rs10149689 TSHR 1.56 0.001 232 vs 163 Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.72 0.01 152 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR7 alleles DR7 Candidate Region/Gene 9425225
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 2.03 0.001 336 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR11 alleles DR11 Candidate Region/Gene 9425225
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination 3.19 0.0006 208 vs 514 Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    rs1800896 IL10 0.031 119 vs 118 Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.46 0.01 488 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR13 alleles DR13 Candidate Region/Gene 9425225
    GSTT1 deletion GSTT1 0.03 94 vs 418 Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
    G1691A F5 0.004 432 vs 184 Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs1799752 ACE 0.016 12 vs 190 vs 105 Greek 99-111 D I Candidate Region/Gene 23389097
    rs5882 CETP 0.05 300 vs 320 vs 258 Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
    T-455C APOC3 0.005 183 vs 110 Russian 70-106 T C Candidate Region/Gene 11193221
    ACE D/I ACE 0.02 689 Danish Minimum age 73 II DI, DD Candidate Region/Gene 12547486
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian G,C T Candidate Region/Gene 19249341
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    • 25 of 344 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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