Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
    rs2149954 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
    STR variation CSF1TPO 0.003 60 vs 250 Chinese >90 low variation in STRs high variation in STRs - 20582731
    DR7 HLA-DRB1 0.01 325 centenarians versus 229 nonagenarian siblings French - 9425225
    DR11 HLA-DRB1 0.01 325 centenarians versus 229 nonagenarian siblings French - 9425225
    DR13 HLA-DRB1 0.01 325 centenarians versus 229 nonagenarian siblings French - 9425225
    rs189037 ATM 1.85 0.028 128 vs 150 Italian - 22960875
    F5 G1691A F5 0.002 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (343 women and 89 men). Polish >95 years versus 44 years - 20720309
    9 mtDNA haplogroups mtDNA haplogroup 0.38 0.025 98 vs. 117 Chinese 90-100 years old J non-J - 18759861
    rs429358, rs7412 APOE 0.009 1477 total Italian 18-109 e4 non-e4 - 16896546
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 Italian age 99–109,years, mean age 101 years; 26 men, 111 women Candidate Region/Gene 16799135
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young Italian 91+ (very old), 73-91 (old) G C Candidate Region/Gene 23125046
    APOE e2/e3/e4 APOE 4.40 0.02 179 Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.72 0.01 152 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR7 alleles DR7 Candidate Region/Gene 9425225
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 2.03 0.001 336 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR11 alleles DR11 Candidate Region/Gene 9425225
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination 3.19 0.0006 208 vs 514 Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    rs1800896 IL10 0.031 119 vs 118 Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    HLA-DRB1 13 generic DRB1 alleles HLA-DRB1 1.46 0.01 488 vs 2950 208 vs original 2950 French 100+ and 90+ siblings non-DR13 alleles DR13 Candidate Region/Gene 9425225
    G1691A F5 0.004 432 vs 184 Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs1799752 ACE 0.016 12 vs 190 vs 105 Greek 99-111 D I Candidate Region/Gene 23389097
    ACE D/I ACE 0.02 689 Danish Minimum age 73 II DI, DD Candidate Region/Gene 12547486
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian G,C T Candidate Region/Gene 19249341
    ADA genotypes ADA 0.003 62 vs 64 vs143 vs 272 Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
    rs1800629 TNF 0.019 747 Italian 19-110 A G Candidate Region/Gene 18511747
    rs1800795 IL-6 0.018 285 Finn 90-95 C G Candidate Region/Gene 15664628

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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